| Identifikační kód |
RIV/00216208:11160/22:10450135 |
| Název v anglickém jazyce |
Study of rheological and tableting properties of lubricated mixtures of co-processed dry binders for orally disintegrating tablets |
| Druh |
J - Recenzovaný odborný článek (Jimp, Jsc a Jost) |
| Poddruh |
J/A - Článek v odborném periodiku je obsažen v databázi Web of Science společností Thomson Reuters s příznakem „Article“, „Review“ nebo „Letter“ (Jimp) |
| Jazyk |
eng - angličtina |
| Vědní obor |
30104 - Pharmacology and pharmacy |
| Rok uplatnění |
2022 |
| Kód důvěrnosti údajů |
S - Úplné a pravdivé údaje o výsledku nepodléhající ochraně podle zvláštních právních předpisů. |
| Počet výskytů výsledku |
2 |
| Popis výsledku v anglickém jazyce |
Co-processed dry binders for ODTs are important multifunctional excipients for tablet manufacturing by direct compression. Testing their binary mixtures with lubricants is an important aspect of their use in combination with drugs. The aim of this study was to evaluate the rheological and compression properties of lubricated mixtures of co-processed dry binders Parteck (R) ODT, Prosolv (R) ODT G2 and Ludiflash (R), and subsequently also the compactability and disintegration time of the tablets made thereof. The lubricants employed were magnesium stearate and sodium stearyl fumarate in the concentrations of 0.5% and 1%. The best flowability was shown by Prosolv (R) ODT G2 combined with magnesium stearate in the concentration of 0.5%. Lubricated mixtures with Prosolv (R) ODT G2 showed a lower angle of internal friction as well as lower pre-compression energy values. The values of plastic deformation energy were the highest in the case of Prosolv (R) ODT G2, which was also reflected in the highest tablet strength. On the contrary, the ejection force values were the lowest for this co-processed dry binder. Magnesium stearate reduced the ejection force more effectively than sodium stearyl fumarate. Prosolv (R) ODT G2 tablets exhibited the highest tensile strength and shortest disintegration time. |
| Klíčová slova oddělená středníkem |
Disintegration time;Compactability;Energy profile of compression;Flow properties;Co-processed dry binders;Orally disintegrating tablets |
| Stránka www, na které se nachází výsledek |
https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RUztnexlvQ |
| DOI výsledku |
10.1016/j.ejps.2021.106035 |
| Odkaz na údaje z výzkumu |
- |